International Journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN: 2313-626X

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 Volume 11, Issue 2 (February 2024), Pages: 57-62

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 Original Research Paper

Lotus toot extract: An investigation of its antioxidant and anticancer properties for potential application in functional foods

 Author(s): 

 Abdulkarim S. Binshay 1, *, Fahad M. Aldakheel 2, Ghfren S. Aloraini 1

 Affiliation(s):

 1Department of Medical Laboratory Science, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia
 2Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia

 Full text

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 * Corresponding Author. 

  Corresponding author's ORCID profile: https://orcid.org/0000-0001-7663-3443

 Digital Object Identifier (DOI)

 https://doi.org/10.21833/ijaas.2024.02.008

 Abstract

This study investigates the effects of lotus root extract (LRE) on antioxidants and cancer prevention to understand how lotus can be used as a natural ingredient in health-promoting foods. We tested the extract's ability to neutralize harmful molecules using the DPPH assay and found that its effectiveness increases with the amount of extract used. The concentration of 22.21 g/mL was key for the extract to show its protective effects. Additionally, our research showed that LRE is good at removing harmful substances like nitrite (21.14 µg/mL) and hydrogen peroxide (24.91 µg/mL). Importantly, lotus extracts were especially effective against human breast cancer cells. Through MTT analysis at 15.60 g/mL, we found LRE to be very effective in killing these cancer cells. This killing process involves the increase of certain proteins (p53, caspase 3, and 9) and the breaking up of DNA, which are signs of cancer cells being programmed to die. Our findings indicate that LRE could be a strong candidate for cancer prevention. This research sheds light on how lotus root extract could be used in health-promoting foods and suggests it might be worth exploring more as a treatment against cancer.

 © 2024 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords

 Lotus root extract, Antioxidant, Anticancer effects, Radical-scavenging activity, Functional foods

 Article history

 Received 10 April 2023, Received in revised form 28 July 2023, Accepted 22 January 2024

 Funding 

The authors extend their appreciation to the Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia, for funding this research work through the project number (IF2/PSAU/2022/03/22422).

 Acknowledgment 

The authors are thankful to the Deanship of Research at Prince Sattam Bin Abdulaziz University for funding this work under the General Research Funding program grant code number (IF2/PSAU/2022/03/22422).

 Compliance with ethical standards

 Conflict of interest: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

 Citation:

 Binshay AS, Aldakheel FM, and Aloraini GS (2024). Lotus toot extract: An investigation of its antioxidant and anticancer properties for potential application in functional foods. International Journal of Advanced and Applied Sciences, 11(2): 57-62

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 Figures

 Fig. 1 Fig. 2 Fig. 3 Fig. 4 

 Tables

 Table 1 Table 2 

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