International journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN:2313-626X

Frequency: 12
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 Volume 4, Issue 12 (December 2017), Pages: 125-132

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 Review Paper

 Title: A review of human genome project (HGP) from ethical perspectives

 Author(s): Engku Ahmad Zaki Engku Alwi 1, Norazmi Anas 2, *, Zakiah Samori 3, Zuriani Yaacob 4, Wan Rohani Wan Taib 5, Mohd Hudzari Razali 6, Syarilla Iryani Ahmad Saany 7

 Affiliation(s):

 1Faculty of Islamic Contemporary Studies, Universiti Sultan Zainal Abidin, Terengganu, Malaysia
 2Academy of Contemporary Islamic Studies, Universiti Teknologi MARA, Perak Branch, Tapah Campus, Perak, Malaysia
 3Academy of Contemporary Islamic Studies, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia
 4Academy of Language Studies, Universiti Teknologi MARA, Pahang Branch, Raub Campus, Pahang, Malaysia
 5Institute for Community [Health] Development, Universiti Sultan Zainal Abidin, Terengganu, Malaysia
 6Faculty of Plantation and Agrotechnology, Universiti Teknologi MARA, Melaka Branch, Jasin Campus, Melaka, Malaysia
 7Academic Quality and e-Learning Centre, Universiti Sultan Zainal Abidin, Terengganu, Malaysia

 https://doi.org/10.21833/ijaas.2017.012.023

 Full Text - PDF          XML

 Abstract:

The human genome is the collection of DNA in the nucleus of human cells. It contains twenty-three pairs of chromosomes and serves as identification marks or blueprints. These distinct structures differentiate humans from other living organisms such as microorganisms, flora, and fauna. Despite this groundbreaking increase in human genetics knowledge, it has led to the emergence of complex ethical, legal and social issues particularly related to the Human Genome Project (HGP). Therefore, this paper intends to provide much deeper insights into the study of concepts, applications of modern genetics and human genetics issues that may arise in contemporary society and the Human Genome Project from ethical perspective in science. Apparently, this study employed descriptive literature review and the results show that the Human Genome Project has significantly increased the level of understanding of the basic damage or genetic defects, the structure of DNA, the identification of the position of all genes and human genome databases as well as HGP major contributions in the field of biology specifically in developmental biology and neurobiology. This indicates that the Human Genome Project has opened up a new era in modern biotechnology that may improve life quality of mankind. Nevertheless, the newfound genetic knowledge or any HGM-related research should be based on ethics known as ELSI (Ethical, Legal and Social Implications) so that it does not damage the population and the descendants of the human beings. 

 © 2017 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: HGP, ELSI, Human Genetic

 Article History: Received 7 August 2017, Received in revised form 12 October 2017, Accepted 13 October 2017

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2017.012.023

 Citation:

 Engku Alwi EAZ, Anas N, Samori Z, Yaacob Z, Taib WRW, Razali MH,  and Saany SIA (2017). A review of human genome project (HGP) from ethical perspectives. International Journal of Advanced and Applied Sciences, 4(12): 125-132

 Permanent Link:

 http://www.science-gate.com/IJAAS/V4I12/Alwi.html

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 References (58)

  1. Al-Hayani FA (2008). Muslim perspectives on stem cell research and cloning. Journal of Religion and Science, 43(4): 783-795. https://doi.org/10.1111/j.1467-9744.2008.00960.x 
  2. Amin L (2013). Modern biotechnology: Malaysian perspective. University of Malaya Press, Malaysia.     
  3. Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA, Abecasis GR, and 1000 Genomes Project Consortium (2015). A global reference for human genetic variation, Nature, 526: 68-74. https://doi.org/10.1038/nature15393  PMid:26432245  PMCid:PMC4750478     
  4. Brockopp JE (2008). Islam and bioethics: Beyond abortion and euthanasia. Journal of Religious Ethics, 36(1): 3-12. https://doi.org/10.1111/j.1467-9795.2008.00333.x 
  5. Brooker R (2015). Concepts of genetics. McGraw-Hill Higher Education, Pennsylvania Plaza, New York, USA.     
  6. Brown T (2011) Introduction to genetics: A molecular approach. Garland Science Publishing, New York, USA.     
  7. Collins FS, Patrinos A, Jordan E, Aravinda C, Gesteland R, and Walters L (1998). New goals for the U.S. Human Genome Project: 1998 –2003. Science, 282: 682-689. https://doi.org/10.1126/science.282.5389.682  PMid:9784121 
  8. Croce N (2016). The science and technology behind the human genome project. Britannica Educational Publishing, New York, USA.     
  9. Dale JW, Schantz MV, and Plant N (2011). From genes to genomes: Concepts and applications of DNA technology. 3rd Edition, John Wiley and Sons, Hoboken, New Jersey, USA.     
  10. Engdahl S (2006). Cloning. Thomson Gale, Detroit, USA.     
  11. Gilbert PR (2008). Advances in biotechnology. Anmol Publications Pvt. Ltd., New Delhi, India.     
  12. Gopal GJ and Kumar A (2013). Strategies for the production of recombinant protein in Escherichia coli. The Protein Journal, 32(6): 419-425. https://doi.org/10.1007/s10930-013-9502-5 PMid:23897421     
  13. Green ED, Watson JD, and Collins FS (2015). Twenty-five years of big biology. Nature, 526: 29-31. https://doi.org/10.1038/526029a  PMid:26432225  PMCid:PMC5101944 
  14. Harley CB and Reynolds RP (1987). Analysis of E. coli pormoter sequences. Nucleic Acids Research, 15(5): 2343-2361. https://doi.org/10.1093/nar/15.5.2343  PMid:3550697  PMCid:PMC340638     
  15. Hartl DL (2012) Essential genetics: A genomics perspective. 6th Edition, Jones and Bartlett Learning, Burlington, Massachusetts, USA.     
  16. Hartl DL and Ruvolo M (2011). Genetics: analysis of genes and genomes. 8th Edition, Jones and Bartlett Learning, Burlington, Massachusetts, USA.     
  17. Hawley DK and McClure WR (1983). Compilation and analysis of Escherichia coli promoter DNA sequences. Nucleic Acids Research, 11(8): 2237-2255. https://doi.org/10.1093/nar/11.8.2237 PMid:6344016  PMCid:PMC325881     
  18. Ignacimuthu S (2009) Bioethics. Alpha Science International Ltd, Oxford, UK.     
  19. Islam S, Nordin RB, and Noor HBM (2012). Ethics of human cloning: A comparative study of Western secular and Islamic bioethics perspectives. Bangladesh Journal of Medical Science, 11(4): 258-266. https://doi.org/10.3329/bjms.v11i4.12595 
  20. Khan FA (2011). Biotechnology fundamentals. CRC Press, Boca Raton, Florida, USA.     
  21. Klug WS, Cummings MR, Spencer C and Palladino M (2014). Concepts of genetics. 10th Edition. Pearson Education Limited, Harlow, UK.     
  22. Lee TF (2013). The human genome project: Cracking the genetic code in life. Springer, New York, USA.     
  23. Lewis R (2007). Human genetics: Concepts and applications. 7th Edition, McGraw Hill, New York, USA.     
  24. Lewis R (2012). Human genetics: Concepts and applications. 10th Edition, McGraw Hill, New York, USA.     
  25. Liu L, Yang H, Shin HD, Chen RR, Li J, Du G, and Chen J (2013). How to achieve high-level expression of microbial enzymes: Strategies and perspectives. Bioengineered, 4(4): 212-223. https://doi.org/10.4161/bioe.24761  PMid:23686280  PMCid:PMC3728192 
  26. Majeed ABA (2002). Bioethics: Ethics in the biotechnology century. Institute of Islamic Understanding Malaysia, Kuala Lumpur, Malaysia.     
  27. Marcus A (2010). Human Genetics: An Overview. Alpha Science International Ltd., Oxford, UK.     
  28. Meager KM and Lee LM (2016). Integrating public health and deliberative public bioethics: Lessons from the human genome project ethical, legal, and social implications program. Public Health Reports, 131(1): 44-51. https://doi.org/10.1177/003335491613100110  PMid:26843669  PMCid:PMC4716471     
  29. Miglani GS (2008). Fundamentals of genetics. Alpha Science International Limited, Oxford, UK. PMid:19075051 PMCid:PMC2663096     
  30. Oliphant AR and Struhl K (1988). Defining the consensus sequences of E. coli promoter elements by random selectio. Nucleic Acids Research, 16(15): 7673-7684. https://doi.org/10.1093/nar/16.15.7673  PMid:3045761  PMCid:PMC338434 
  31. Panofsky A (2015). The material gene: Gender, race, and heredity after the human genome project: A review. Contemporary Sociology, 44(2): 207-209. https://doi.org/10.1177/0094306115570271u 
  32. Parrington J (2015). The deeper genome: why there is more to the human genome than meets the eye. Oxford University Press, Oxford, UK.     
  33. Pawel J and Wong TS (2015). From genetic circuits to industrial-scale biomanufacturing: bacterial promoters as a cornerstone of biotechnology. AIMS Bioengineering, 2(3): 277-296. https://doi.org/10.3934/bioeng.2015.3.277 
  34. Pierce BA (2010) Genetics: A conceptual approach. W. H. Freeman and Company, New York, USA.     
  35. Plopper G, Sharp D, and Sikorski E (2013). Lewin's cells. 3rd Edition, Jones and Bartlett Learning, Burlington, Massachusetts, USA.     
  36. Purohit SS (2005). Biotechnology: Fundamentals and applications. Agrobios India Publishers, Jodhpur, India.     
  37. Rajasekaran K, Jacks TJ, and Finley JW (2002). Crop biotechnology. American Chemical Society, Washington DC, USA. https://doi.org/10.1021/bk-2002-0829 
  38. Rastogi S and Pathak N (2009). Genetic engineering. Oxford University Press, Oxford, UK.     
  39. Richards JE and Hawley RS (2010). The human genome: A user's guide. Academic Press, Cambridge, Massachusetts, USA.     
  40. Roberts D (2010). 12 race and the new biocitizen. In: Whitmarsh I and Jones DS (Eds.), What's the use of race?: 259-276. Modern Governance and the Biology of Difference, The MIT Press, Cambridge, Massachusetts, USA.     
  41. Rosano GL and Ceccarelli EA (2014). Recombinant protein expression in Escherichia coli: Advances and challenges. Frontiers in Microbiology, 5(172): 1-17. https://doi.org/10.3389/fmicb.2014.00172 
  42. Roy D (2010). Biotechnology. Alpha Science International Ltd., Oxford, UK.     
  43. Russell PJ (2006). iGenetics: A molecular approach. Pearson/Benjamin Cummings, San Fracisco, California, USA.     
  44. Saifuddeen SM, Roslili WAM, and Sobian A (2005). Sempadan bioteknologi menurut perspektif Islam. Institut Kefahaman Islam Malaysia, Kuala Lumpur, Malaysia.     
  45. Sanderson CJ (2007). Understanding genes and GMOs. Worlds Scientific Publishing Co, Singapore, Singapore. https://doi.org/10.1142/6304 
  46. Schiffels S and Durbin R (2014). Inferring human population size and separation history from multiple genome sequences. Nature Genetics, 46(8): 919-927. https://doi.org/10.1038/ng.3015 PMid:24952747  PMCid:PMC4116295     
  47. Sekaleshfar FB (2010). A critique of Islamic arguments on human cloning. Journal of Religion and Science, 45(1):37-46. https://doi.org/10.1111/j.1467-9744.2010.01057.x 
  48. Slatkin M and Racimo F (2016). Ancient DNA and human history. Proceedings of the National Academy of Sciences, 113(23): 6380-6387. https://doi.org/10.1073/pnas.1524306113 PMid:27274045  PMCid:PMC4988579     
  49. Smith JE (1988). Biotechnology. Edward Arnold, London, UK.     
  50. Smith JE (2009) Biotechnology. Cambridge University Press, Cambridge, USA. https://doi.org/10.1017/CBO9780511802751 
  51. Snustad DP and Simmons MJ (2012). Genetics. 6th Edition. International student version, John Wiley and Sons, Singapore, Singapore.     
  52. Strachan T and Read A (2010). Human molecular genetics. 4th Edition, Taylor and Francis Group, Garland Science, New York, USA.     
  53. Telenti A, Pierce LCT, Biggs WH, di Iulio J, Wong EHM, Fabani MM, and Kirkness EF (2016). Deep sequencing of 10,000 human genomes. In the Conference of the National Academy of Sciences, 113(42): 11901–11906. https://doi.org/10.1073/pnas.1613365113  PMid:27702888 PMCid:PMC5081584     
  54. Thieman WJ and Palladino MA (2012). Introduction to biotechnology. Pearson, Boston, USA. PMCid:PMC3354769     
  55. Tramper J and Zhu Y (2011). Modern biotechnology: Panacea or new Pandora's box?. Springer, Berlin, Germany. https://doi.org/10.3920/978-90-8686-725-7 
  56. Vihinen M, Hancock JM, Maglott DR, Landrum MJ, and Schaafsma GCP (2016). Human variome project quality assessment criteria for variation databases. Human Mutation, 37(6): 549–558. https://doi.org/10.1002/humu.22976  PMid:26919176 
  57. Whitmarsh I and Jones DS (2010). Governance and the Uses of Race. In: Whitmarsh I and Jones DS (Eds.), What's the use of race? Modern Governance and the Biology of Difference. The MIT Press, Cambride, Massachusetts, USA.     
  58. Wilson BJ and Nicholls SG (2015). The human genome project and recent advances in personalized genomics. Risk Management and Healthcare Policy, 8: 9-20. https://doi.org/10.2147/RMHP.S58728  PMid:25733939  PMCid:PMC4337712