International Journal of Advanced and Applied Sciences
Int. j. adv. appl. sci.
EISSN: 2313-3724
Print ISSN:2313-626X
Volume 3, Issue 7 (July 2016), Pages: 69-74
Title: Analyzing the effect of MicroRNAs on Hepatogenic differentiation of Mesenchymal stem cells
Authors: Ehsan Jahangirian *, Seyed Moayed Alavian
Affiliations:
Baqiyatallah Research Center for Gastroenterology and Liver Disease Baqiyatallah University of Medical Sciences, Tehran, Iran
http://dx.doi.org/10.21833/ijaas.2016.07.011
Abstract:
This research aims at analyzing the effect of microRNAs on hepatogenic Differentiation of mesenchymal stem cells. According to the results, miR-1246, miR-1290, miR-148a, miR-30a, miR-424 and miR-542-5p were definitely overexpressed during hepatic differentiation of hMSCs. Also the results indicate that ectopic overexpression of miR-122 cannot initiate hepatic differentiation of hMSCs. In other words, hMSCs can be converted into functional hepatocytes only if all the miRs (miR-122, miR-1246, miR-1290, miR-148a, miR-30a, miR-424, and miR-542-5p) are used.
© 2016 The Authors. Published by IASE.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Hepatogenic, Mesenchymal stem cells, MicroRNAs
Article History: Received 18 May 2016, Received in revised form 25 July 2016, Accepted 26 July 2016
Digital Object Identifier: http://dx.doi.org/10.21833/ijaas.2016.07.011
Citation:
Jahangirian E, Alavian SM (2016). Analyzing the effect of MicroRNAs on Hepatogenic differentiation of Mesenchymal stem cells. International Journal of Advanced and Applied Sciences, 3(7): 69-74
http://www.science-gate.com/IJAAS/V3I7/Jahangirian.html
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