International Journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN: 2313-626X

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 Volume 10, Issue 3 (March 2023), Pages: 114-118

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 Original Research Paper

 Role of luteinizing and follicle-stimulating hormones in women diagnosed with polycystic ovary syndrome

 Author(s): 

 Johara Al-Mutawa *

 Affiliation(s):

 Department of Obstetrics and Gynecology, College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia

  Full Text - PDF          XML

 * Corresponding Author. 

  Corresponding author's ORCID profile: https://orcid.org/0000-0001-5759-4573

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2023.03.015

 Abstract:

The aim of this study was to investigate the relationship between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in women diagnosed with polycystic ovary syndrome (PCOS) in Saudi Arabia and to compare obesity levels. In this case-control study, 101 PCOS women and 54 control subjects were enrolled in King Khalid University Hospital. Based on Rotterdam criteria, PCOS women were enrolled. Anthropometric measurements were collected between PCOS and control women. ANOVA analysis was performed in PCOS women to measure the PCOS variables. The study results demonstrate that LH levels are significantly associated with PCOS women (p=0.06). ANOVA analysis indicated that age (p=0.001) and LH (p=0.05) were significantly related among the age groups. The weight, height, and BMI were significantly associated in PCOS women among PCOS subjects with obesity (p<0.05). This study concludes as LH and FSH levels were high in PCOS women with different forms of obesity and LH is correlated (p=0.06) between PCOS and control women. Additionally, elevated BMI levels were not associated with LH and FSH levels.

 © 2022 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: Polycystic ovary syndrome, Luteinizing hormone, Follicle-stimulating hormone, Obesity, Saudi women

 Article History: Received 21 August 2022, Received in revised form 6 December 2022, Accepted 14 December 2022

 Acknowledgment 

No Acknowledgment.

 Compliance with ethical standards

 Ethical consideration

This study has obtained an ethical grant from the Institutional Review Board at King Saud University (KSU). Saudi women who participated in this study have signed the informed consent form.

 Conflict of interest: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

 Citation:

 Al-Mutawa J (2023). Role of luteinizing and follicle-stimulating hormones in women diagnosed with polycystic ovary syndrome. International Journal of Advanced and Applied Sciences, 10(3): 114-118

 Permanent Link to this page

 Figures

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 Tables

 Table 1 Table 2 Table 3 

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 References (26)

  1. Aboeldalyl S, James C, Seyam E, Ibrahim EM, Shawki HED, and Amer S (2021). The role of chronic inflammation in polycystic ovarian syndrome-A systematic review and meta-analysis. International Journal of Molecular Sciences, 22(5): 2734. https://doi.org/10.3390/ijms22052734   [Google Scholar] PMid:33800490 PMCid:PMC7962967
  2. Abood RM and Hathal HD (2021). Study of anti-ovarian antibody, anti-FSH and Anti-LH antibodies along with their receptors in polycystic ovarian syndrome. Indian Journal of Forensic Medicine and Toxicology, 15(2): 3251-3256.   [Google Scholar]
  3. Abraham Gnanadass S, Divakar Prabhu Y, and Valsala Gopalakrishnan A (2021). Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): An update. Archives of Gynecology and Obstetrics, 303(3): 631-643. https://doi.org/10.1007/s00404-020-05951-2   [Google Scholar] PMid:33439300
  4. Alharbi KK, Khan IA, Al-Sheikh YA, Alharbi FK, Alharbi FK, and Al-Nbaheen MS (2014). Lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population. Acta Biochimica Polonica, 61(4): 1-4. https://doi.org/10.18388/abp.2014_1844   [Google Scholar] PMid:25337779
  5. Al-Mulhim AA, Abul-Heija AA, Al-Talib AA, Al-Turki HA, and Gasim TG (2013). Hormonal, metabolic and clinical profile of Saudi women with polycystic ovary syndrome. Saudi Journal of Medicine and Medical Sciences, 1(1): 30-34. https://doi.org/10.4103/1658-631X.112920   [Google Scholar]
  6. Alnakash AH, and Al-Tae e NK (2007). Polycystic ovarian syndrome: the correlation between the LH/FSH ratio and disease manifestations. Middle East Fertility Society Journal, 12(1): 35-40.   [Google Scholar]
  7. Alshammary AF and Khan IA (2021). Screening of obese offspring of first-cousin consanguineous subjects for the angiotensin-converting enzyme gene with a 287-bp Alu sequence. Journal of Obesity and Metabolic Syndrome, 30(1): 63-71. https://doi.org/10.7570/jomes20086   [Google Scholar] PMid:33653971 PMCid:PMC8017326
  8. AlSinan A and Shaman AA (2017). A study to measure the health awareness of polycystic ovarian syndrome in Saudi Arabia. Global Journal of Health Science, 9(8): 130-138. https://doi.org/10.5539/gjhs.v9n8p130   [Google Scholar]
  9. Balen AH, Laven JS, Tan SL, and Dewailly D (2003). Ultrasound assessment of the polycystic ovary: international consensus definitions. Human Reproduction Update, 9(6): 505-514. https://doi.org/10.1093/humupd/dmg044   [Google Scholar] PMid:14714587
  10. Beydoun HA, Beydoun MA, Wiggins N, and Stadtmauer L (2012). Relationship of obesity-related disturbances with LH/FSH ratio among post-menopausal women in the United States. Maturitas, 71(1): 55-61. https://doi.org/10.1016/j.maturitas.2011.10.010   [Google Scholar] PMid:22088801 PMCid:PMC3398813
  11. Bogari NM (2020). Genetic construction between polycystic ovarian syndrome and type 2 diabetes. Saudi Journal of Biological Sciences, 27(10): 2539-2543. https://doi.org/10.1016/j.sjbs.2020.05.004   [Google Scholar] PMid:32994709 PMCid:PMC7499096
  12. Burghen GA, Givens JR, and Kitabchi AE (1980). Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. The Journal of Clinical Endocrinology and Metabolism, 50(1): 113-116. https://doi.org/10.1210/jcem-50-1-113   [Google Scholar] PMid:7350174
  13. Daghestani MH (2018). Evaluation of biochemical, endocrine, and metabolic biomarkers for the early diagnosis of polycystic ovary syndrome among non‐obese Saudi women. International Journal of Gynecology and Obstetrics, 142(2): 162-169. https://doi.org/10.1002/ijgo.12527   [Google Scholar] PMid:29745981
  14. de Castro F, Ruiz R, Montoro L, Pérez-Hernández D, Padilla ESC, Real LM, and Ruiz A (2003). Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone. Fertility and Sterility, 80(3): 571-576. https://doi.org/10.1016/S0015-0282(03)00795-7   [Google Scholar] PMid:12969700
  15. Fulghesu AM, Piras C, Dessì A, Succu C, Atzori L, Pintus R, and Fanos V (2021). Urinary metabolites reveal hyperinsulinemia and insulin resistance in polycystic ovarian syndrome (PCOS). Metabolites, 11(7): 437. https://doi.org/10.3390/metabo11070437   [Google Scholar] PMid:34357331 PMCid:PMC8307496
  16. Haller K, Salumets A, and Uibo R (2008). Anti-FSH antibodies associate with poor outcome of ovarian stimulation in IVF. Reproductive Biomedicine Online, 16(3): 350-355. https://doi.org/10.1016/S1472-6483(10)60595-0   [Google Scholar] PMid:18339255
  17. Hu L, Shen H, Wu QF, Tian L, and Hu MH (2014). Treatment of polycystic ovarian syndrome with insulin resistance by insulin-sensitizer. Clinical and Experimental Obstetrics and Gynecology, 41(3): 288-292. https://doi.org/10.12891/ceog16222014   [Google Scholar]
  18. Khan IA, Jahan P, Hasan Q, and Rao P (2019). Genetic confirmation of T2DM meta-analysis variants studied in gestational diabetes mellitus in an Indian population. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13(1): 688-694. https://doi.org/10.1016/j.dsx.2018.11.035   [Google Scholar] PMid:30641791
  19. Kiddy DS, Sharp PS, White DM, Scanlon MF, Mason HD, Bray CS, and Franks S (1990). Differences in clinical and endocrine features between obese and non‐obese subjects with polycystic ovary syndrome: An analysis of 263 consecutive cases. Clinical Endocrinology, 32(2): 213-220. https://doi.org/10.1111/j.1365-2265.1990.tb00857.x   [Google Scholar] PMid:2112067
  20. Lal L, Bharti A, and Perween A (2017). To study the status of LH: FSH ratio in obese and non-obese patients of polycystic ovarian syndrome. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS), 16(01): 20-23. https://doi.org/10.9790/0853-1601012023   [Google Scholar]
  21. Morshed MS, Banu H, Akhtar N, Sultana T, Begum A, Zamilla M, and Hasanat MA (2021). Luteinizing hormone to follicle-stimulating hormone ratio significantly correlates with androgen level and manifestations are more frequent with hyperandrogenemia in women with polycystic ovary syndrome. Journal of Endocrinology and Metabolism, 11(1): 14-21. https://doi.org/10.14740/jem716   [Google Scholar]
  22. Prabhu BN, Kanchamreddy SH, Sharma AR, Bhat SK, Bhat PV, Kabekkodu SP, and Rai PS (2021). Conceptualization of functional single nucleotide polymorphisms of polycystic ovarian syndrome genes: an in silico approach. Journal of Endocrinological Investigation, 44(8): 1783-1793. https://doi.org/10.1007/s40618-021-01498-4   [Google Scholar] PMid:33506367 PMCid:PMC8285346
  23. Saadia Z (2020). Follicle stimulating hormone (LH: FSH) ratio in polycystic ovary syndrome (PCOS)-Obese vs. non-obese women. Medical Archives, 74(4): 289-293. https://doi.org/10.5455/medarh.2020.74.289-293   [Google Scholar] PMid:33041447 PMCid:PMC7520057
  24. Schmidt J, Brännström M, Landin-Wilhelmsen K, and Dahlgren E (2011). Reproductive hormone levels and anthropometry in postmenopausal women with polycystic ovary syndrome (PCOS): A 21-year follow-up study of women diagnosed with PCOS around 50 years ago and their age-matched controls. The Journal of Clinical Endocrinology and Metabolism, 96(7): 2178-2185. https://doi.org/10.1210/jc.2010-2959   [Google Scholar] PMid:21508129
  25. Šimková M, VÍTKŮ J, Kolatorova L, Vrbikova J, Vosatkova M, VČELÁK J, and Dušková M (2020). Endocrine disruptors, obesity, and cytokines-How relevant are they to PCOS? Physiological Research, 69(2): S279-S293. https://doi.org/10.33549/physiolres.934521   [Google Scholar] PMid:33094626 PMCid:PMC8603732
  26. Stein IF and Leventhal ML (1935). Amenorrhea associated with bilateral polycystic ovaries. American Journal of Obstetrics and Gynecology, 29(2): 181-191. https://doi.org/10.1016/S0002-9378(15)30642-6   [Google Scholar]