International Journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN: 2313-626X

Frequency: 12
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 Volume 9, Issue 12 (December 2022), Pages: 114-124

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 Original Research Paper

The nutritional evaluation of Ruthana date fruits (Phoenix dactylifera L.) with its role in controlling free radicals and anti-inflammatory activities

 Author(s): Nosiba A. Alsarayrah 1, Saud M. Alsanad 2, Hasni Arsad 1, Mubark M. Abudahash 3, Fouza K. Alenazi 3, Naif D. Alenzi 3, Eshaifol A. Omar 1, *

 Affiliation(s):

 1Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, 13200 Kepala Batas, Pulau Pinang, Malaysia
 2Imam Mohammad Ibn Saud Islamic University, Riyadh 11564, Saudi Arabia
 3Research and Laboratories Sector, National Drug and Cosmetic Control Laboratories (NDCCL), Saudi Food and Drug Authority, Riyadh, Saudi Arabia

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 * Corresponding Author. 

  Corresponding author's ORCID profile: https://orcid.org/0000-0002-7000-7836

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2022.12.015

 Abstract:

In this study, the polyphenol content was measured and the potential therapeutic value of the methanolic extract of Ruthana dates grown in Saudi Arabia was analyzed. The results showed that the Ruthana dates contain a high percentage of phenols and flavonoids, reaching 119.2 %, and 55.6 %, respectively. The antioxidant activity was also measured by several methods. The methanol extract of Ruthana showed significant effectiveness in inhibiting free radicals in the DPPH test. The highest inhibition rate was (79%) with an IC50 value of (3.97±0.21 mg Trolox/g plant), and (3.9035±0.380 μg/ml) on nitric oxide radical. The FRAP and ABTS tests showed higher sensitivity to antioxidants with IC50 values (4.08±0.26 mg of Trolox/ g of plant extract, and 4.18±0.26 mg of TEAC/ g of plant extract), respectively. The antioxidant activity was significantly correlated with the anti-inflammatory activity, the methanolic extract showed activity in preventing heat-catalyzed protein denaturation with a ratio of (74%), and IC50 (3.835±0.380 µg/ml), and at RBC'S membrane stabilization the effectiveness of the extract reached (68%) with IC5 value (6.215±0.238 µg/ml). The results showed a concordance between the phenolic content and the antioxidant and anti-inflammatory activity. Accordingly, the fruits of Ruthana dates constitute a promising possibility for isolating the active compounds and introducing them into the pharmaceutical industries in the future.

 © 2022 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: Polyphenols, Phoenix dactylifera L., Ruthana fruits, Anti-oxidants, Anti-inflammatory

 Article History: Received 5 May 2022, Received in revised form 17 July 2022, Accepted 2 September 2022

 Acknowledgment 

The work reported in this study is funded by the Universiti Sains Malaysia (USM), RESEARCH UNIVERSITY (RU) GRANT (1001/CIPPT/8012332). The authors would like to thank USM for its invaluable support of this study.

 Compliance with ethical standards

 Conflict of interest: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

 Citation:

 Alsarayrah NA, Alsanad SM, Arsad H, Abudahash MM, Alenazi FK, Alenzi ND, and Omar EA (2022). The nutritional evaluation of Ruthana date fruits (Phoenix dactylifera L.) with its role in controlling free radicals and anti-inflammatory activities. International Journal of Advanced and Applied Sciences, 9(12): 114-124

 Permanent Link to this page

 Figures

 Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9 Fig. 10 Fig. 11 

 Tables

 Table 1 Table 2 Table 3 Table 4 Table 5

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