International Journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN: 2313-626X

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 Volume 8, Issue 5 (May 2021), Pages: 122-129

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 Review Paper

 Title: Effects of coconut oil on Alzheimer disease

 Author(s): Tahani Ahmad Al-Matrafi *

 Affiliation(s):

 Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

  Full Text - PDF          XML

 * Corresponding Author. 

  Corresponding author's ORCID profile: https://orcid.org/0000-0001-8098-2398

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2021.05.013

 Abstract:

Dementia is a general term for loss of memory, language, problem-solving, and other thinking abilities that are severe enough to interfere with daily life. Alzheimer's disease (AD) is the most common cause of dementia. Risk factors as age, genetics, environment, lifestyle, and metabolic disease. The etiology of AD remains not fully explained, but both genetic and environmental risk factors have been proposed to be involved. Microscopically, intraneuronal neurofibrillary tangles (NFTs) and extracellular senile plaques characterize the AD. The amyloid cascade hypothesis (ACH) suggests that the imbalance between the Amyloid-β generation and its clearance causes dysfunction and consequently cell death. Coconut oil may represent a cheap and natural treatment for AD. This is because coconut oil contains medium-chain triglycerides (MCTs), which are digested to ketones in the liver that are linked to mitochondrial function enhancement and oxidation-reduction. Recent studies have investigated the possibility of using trans-zeatin and phytoestrogen and other sex hormones like substances present in coconut water and a young coconut juice (YCJ) in reducing the chance of AD. Coconut is known as a 'functional food' that is extremely nutritious. Virgin coconut oil (VCO) differs from ordinary coconut oil as the former contains a lot more biologically active components. Phenolic compounds and hormones contained in coconut can help prevent amyloid b peptide aggregation, potentially inhibiting a key step in the pathogenesis of AD. Coconut can be useful in the treatment of obesity, dyslipidemia, elevated low-density lipoproteins, insulin resistance, and hypertension-these are the risk factors for chronic venous disease and type II diabetes, as well as for AD. 

 © 2021 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: Alzheimer’s disease, Neurofibrillary tangles, Amyloid cascade hypothesis, Medium-chain triglycerides, Young coconut juice, Virgin coconut oil

 Article History: Received 19 November 2020, Received in revised form 31 January 2021, Accepted 6 February 2021

 Acknowledgment 

No Acknowledgment.

 Compliance with ethical standards

 Conflict of interest: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

 Citation:

  Al-Matrafi TA (2021). Effects of coconut oil on Alzheimer disease. International Journal of Advanced and Applied Sciences, 8(5): 122-129

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