International Journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN: 2313-626X

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 Volume 7, Issue 2 (February 2020), Pages: 69-77

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 Original research Paper

 Title: Evaluation of some new synthesis benzothiazole and benzimidazole derivatives as potential antimicrobial and anticancer agents

 Author(s): Amani Abd Elrazig Salman Abd Elaziz 1, *, Ahmed M. Farag 2, Ishraga Izzeldin Abdelrahim Alagib 1, Emad M. Abdallah 3, Nawadir Eltieb Abdlla Mohammed 1

 Affiliation(s):

 1Department of Basic Science (Chemistry), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
 2Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
 3Department of Laboratory Sciences, College of Sciences and Arts, Qassim University, Al-Rass, Saudi Arabia

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 * Corresponding Author. 

  Corresponding author's ORCID profile: https://orcid.org/0000-0003-0525-6307

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2020.02.010

 Abstract:

There is an urgent global need to develop new antimicrobial and anti-cancer drugs. In the current study, the biological evaluation of some synthesized phenylsulfonyl of benzothiazole and benzimidazole moiety-containing pyrazolo [5, 1-c]-l, 2, 4-triazine derivative [6, 7, 11.12, 16 and 17], arylhydrazone derivatives and pyridazine derivative [20, 21, 25, 26, 29 and 29] was carried out for antimicrobial and anticancer activity. The synthesized compounds containing pyrazolo [5, 1-c]-l, 2, 4-triazine derivative [6, 7] exhibited higher activity against Staphylococcus aureus compared with control drug Chloramphenicol. While arylhydrazones 20 and 21 were found to be equal to the control drug. For antifungal activity, the compounds 6, 7, 20 and 21 were possessed the same potency as cycloheximide against Aspergillus fumigatus. The anticancer activity on Hepatocellular carcinoma (HEPG2) of the compounds 6, 7, 20 and 21 exhibited excellent activities, more potent than the reference drug. The findings of this study are worthwhile; however, further pharmaceutical and toxicological studies are recommended to be carried out. 

 © 2020 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: Benzothiazoles, Benzimidazoles, β-ketosulfones, Pyrazolo[5,1-c]-l,2,4-triazine, Arylhydrazone, Pyridazine, Antimicrobial, Anticancer

 Article History: Received 15 September 2019, Received in revised form 14 December 2019, Accepted 17 December 2019

 Acknowledgment:

No Acknowledgment.

 Compliance with ethical standards

 Conflict of interest:  The authors declare that they have no conflict of interest.

 Citation:

 Abd Elaziz AAES, Farag AM, and Alagib IIA et al. (2020). Evaluation of some new synthesis benzothiazole and benzimidazole derivatives as potential antimicrobial and anticancer agents. International Journal of Advanced and Applied Sciences, 7(2): 69-77

 Permanent Link to this page

 Figures

 Fig. 1 Fig. 2 Fig. 3

 Tables

 Table 1 Table 2 Table 3

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