International journal of

ADVANCED AND APPLIED SCIENCES

EISSN: 2313-3724, Print ISSN:2313-626X

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 Volume 5, Issue 7 (July 2018), Pages: 53-57

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 Original Research Paper

 Title: Antifungal effects of six herbal extracts against Aspergillus sp. and compared to amphotericin B and nystatin

 Author(s): Ahmad Tajehmiri 1, 2, Mohammad Reza Rahmani 3, Seyedeh Sarah Moosavi 4, Kambiz Davari 4, *, Seyedeh Sarah Ebrahimi 4

 Affiliation(s):

 1Nosocomial Infection Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
 2Zist Iman Razi Company, Bistoon Industrial Zone, Kermanshah, Iran
 3Department of Clinical Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
 4Department of Biology, College of Basic Science, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran

 https://doi.org/10.21833/ijaas.2018.07.007

 Full Text - PDF          XML

 Abstract:

Aspergillus is a filamentous fungus of wide distribution having widespread species diversity. Among pathogenic species of Aspergillus, Aspergillus fumigatus, Aspergillus niger, and Aspergillus flavus are regarded as the most important pathogenic agents. The aim of this research is to study the antifungal effects of Artemisia dracunculus L, Achillea wilhelmsii C. Koch, Bunium persicum, Cuminum cyminum L, Zataria multiflora Boiss, and Satureja hortensis extracts against Aspergillus Sp. The herbal extracts were prepared using maceration method. 50gr of ground plant was introduced into a 1-litre flask and macerated with 400ml of 70% ethanol for 24h and then was shaken on shaker. Afterwards, different concentrations of the extract were prepared in dimethyl sulfoxide solvent (DMSO). The extracts were filtered and sterilized. Suspension of each fungus was separately prepared with 1×106 CFU/ml concentration. The antifungal effects of the extracts were measured through NCCLS protocols and Broth dilution method. The control and comparison were done between the antifungal effects of the mentioned herbal extracts and Amphotericin B and Nystatin. The results indicated that the range of MIC and MFC values of these drugs was significantly higher (p≤0.05) compared to the prepared herbal extracts of different dilutions and control group of drug solvent, too. Results showed that the extracts of all herbal extracts have antifungal properties against Aspergillus sp. 

 © 2018 The Authors. Published by IASE.

 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

 Keywords: Anti-fungal effects, Medicinal plants, Aspergillus

 Article History: Received 30 November 2017, Received in revised form 22 April 2018, Accepted 27 April 2018

 Digital Object Identifier: 

 https://doi.org/10.21833/ijaas.2018.07.007

 Citation:

 Tajehmiri A, Rahmani MR, and Moosavi SS et al. (2018). Antifungal effects of six herbal extracts against Aspergillus sp. and compared to amphotericin B and nystatin. International Journal of Advanced and Applied Sciences, 5(7): 53-57

 Permanent Link:

 http://www.science-gate.com/IJAAS/2018/V5I7/Tajehmiri.html

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